Albumin Drug Carriers

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The team at the Children's cancer institute has identified new drugs based in siRNA for the treatment of childhood (neuroblastoma, brain cancer) and adult (lung, pancreatic) cancers. Advantage of these drugs is the higher specificity towards cancer reducing the side effects to healthy tissue. However, these drugs are fragile and often do not reach the target. Nanoparticle can help protecting the drug, but also enhance the targeting towards tumours. In this project, we will develop a drug carrier that is specifically design to enhance the delivery of drugs to pancreatic cancer, a disease that has one of the lowest survival rates among all cancer types. Nanoparticles based on polymer-protein conjugates will be employed that will be tailored made by adjusting the type of the polymer to achieve the highest activity in pancreatic cancer. The student will work in a chemistry lab and develop the nanoparticles, but will spend the second part of the thesis in the Children's cancer institute for in vitro and in vivo studies

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Supervisory team
Martina
Stenzel

Science
Chemistry
Joshua
McCarroll

Medicine
Women's and Children's Health
Paul
DeSouza

Conjoint position in UNSW Medicine and University of Western Sydney
South Western Sydney Clinical School
M.Stenzel@unsw.edu.au

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