Biosensors for the Detection of Minimal Residual Disease in Leukaemia

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Monitoring of minimal residual disease (MRD) during and following combination chemotherapy is one of the most accurate methods of predicting disease outcome in acute leukaemia. However, current techniques rely on sampling from the patient's bone marrow, with its associated morbidity. Circulating tumour DNA can act as a surrogate for the whole cancer cell genome, and can provide highly sensitive and specific cancer diagnostic and prognostic information. This interdisciplinary project aims to develop highly accurate and sensitive biosensors for MRD monitoring in the peripheral blood of acute leukaemia patients, and its successful implementation will have a significant impact on human health.

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Supervisory team
Richard
Lock

Medicine
Women's and Children's Health
Justin
Gooding

Science
Chemistry
Narges
Bayat

Medicine
Women's and Children's Health
rlock@ccia.unsw.edu.au

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