Cancer Nanomedicine: Visualisation and Efficacy of Nanoparticle Delivery

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Childhood cancer is responsible for the greatest number of deaths from disease in developed countries. Survivors frequently have life-long health problems and effective, less toxic, therapies are urgently required. Nanotechnology offers opportunities to develop potent drug delivery vehicles (nanoparticles) targeting cancer cells while sparing normal cells. This study will identify how design (size and shape) of nanoparticles loaded with chemotherapy influences accumulation and drug release within tumours and normal tissues, using intravital microscopy, cell biology and MRI imaging. Advanced understanding of functional design of nanoparticles in vivo will lead to new design principles for nanoparticle-based drug delivery for cancer therapy.

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Supervisory team
Maria
Kavallaris

Medicine
Women's and Children's Health
Thomas
Davis

Medicine
Women's and Children's Health
John
McGhee

Art and Design
Art and Design
m.kavallaris@ccia.unsw.edu.au

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