Cardio-Mimetic Tissue Construct that Mirrors the Anisotropy of the Heart

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This project will explore the integration of conductive polymers into a microstructured hydrogel to coordinate the spatial differentiation of stem cells into a functional cardiac scaffold for managing coronary artery disease. Alternating layers of a polymeric bioink and stem cells will be 3D printed; parameters such as layer and strand configuration, protein composition and cell density, will be investigated to create cell-laden patches with the required biochemical, biophysical and architectural cues. The conductive polymer will be locally deposited in parallel strands to create a cell laden patch that has aligned conductive pathways mimicking the anisotropy of the heart.

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Supervisory team
Kris
Kilian

Science
Chemistry
Damia
Mawad

Science
Materials Science and Engineering
Vashe
Chandrakanthan

Medicine
Women's and Children's Health
kkilian10@gmail.com

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