Chemically Modifying a Drug that Preserves Fertility in Cancer Patients

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Life-saving chemo/radio-therapy commonly renders women and girls who survive cancer infertile or sterile. We have discovered a drug which preserves the fertility of female mice exposed to chemo-radio therapy. In this project we will focus on how to deliver this revolutionary drug to human ovarian tissue/eggs for the first time. In a cross-faculty collaboration, we will focus on how to chemically engineer this new drug for prolonged release from a hydrogel, while still maintaining its biological activity. The project will include chemical synthesis, material characterisation, drug release assays, and in vitro/in vivo experimentation.

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Supervisory team
Penny
Martens

Engineering
Biomedical Engineering
Robert
Gilchrist

Medicine
Women's and Children's Health
Lindsay
Wu

Medicine
Medical Sciences
p.martens@unsw.edu.au

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