Genomic Determinants of Basal Cell Carcinoma Susceptibility

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Basal cell carcinoma is the most common and costly cancer in Australia. It may also be a marker of general high cancer-risk. Sun exposure is an established cause, but the underlying genetic determinants and molecular pathways are unknown. We will reveal the complete DNA sequence of 2000 well characterised individuals with and without this cancer using state-of-the-art whole genome sequencing. We will determine which genes influence a person's risk, and how, and use that information to develop a novel clinical tool to identify those at highest risk. This will allow targeted prevention and early detection, reducing morbidity and healthcare costs.

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Supervisory team
Claire
Vajdic

Medicine
Centre for Big Data Research in Health
Mark
Cowley

Medicine
Garvan Institute
Maarit
Laaksonen

Medicine
Centre for Big Data Research in Health
claire.vajdic@unsw.edu.au

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