How and Where Vaccines Protect us from Infection

Back to search results

Vaccine-induced immunity is mediated by long-lived plasma cells and memory B cells (MBCs). However, where and how MBCs are reactivated to make neutralizing antibodies remain unknown. This project will use CRISPR/Cas gene editing to create genetically-modified mice in which MBCs can be tracked by intravital two-photon microscopy. In addition, MBCs will be highlighted by two-photon photoconversion for single cell transcriptomic analysis to discover the genetic controls that govern the behaviour these cells. This powerful repertoire of state-of-the-art technologies will allow us to make discoveries that will have a major impact on the design of future vaccines to eradicate infectious diseases.

Apply Now
Supervisory team
Tri
Phan

Medicine
St Vincent's Clinical School
Anthony
Kelleher

Medicine
The Kirby Institute
Robert
Brink

Medicine
St Vincent's Clinical School
t.phan@unsw.edu.au

Apply Now

Please start your application by taking the self assessment. Download the editable MS Word version or download the non-editable PDF version (best for Mac or mobile devices). Once the self assessment form is completed, save as a PDF and upload along with your application.

One file only.
50 MB limit.
Allowed types: gif jpg png bmp eps tif pict psd txt rtf html odf pdf doc docx ppt pptx xls xlsx xml avi mov mp3 ogg wav bz2 dmg gz jar rar sit svg tar zip.
If you have not done so, please complete the self assessment PDF as noted above.