How do T cells make decisions? T cell activation is a hallmark of the adaptive immune system. Antigen binding to the T cell receptor (TCR) induces intracellular signalling on which T cell fate decisions are based. Inappropriate decisions can lead to autoimmunity (where the immune system attacks the host organs), or immune deficiencies (where T cells fail to clear infected or cancer cells). To understand how T cell signalling encodes and processes information, our team develops novel super-resolution fluorescence microscopes (e.g. single molecule imaging) and image analyses and employs state-of-the-art molecular biology approaches. Our interdisciplinary training spans cellular immunology, molecular biology, optical physics and applied mathematics.
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