Hybrid Gels as Improved, Tuneable 3D Culture Materials

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The extracellular matrix (ECM) is a fibrous mesh within the body that provides vital chemical and mechanical cues for cell growth, proliferation and migration, which differs in its physical and chemical composition depending on its <i>in vivo</i> location. Thus far, it has proven difficult to synthetically create an ECM which mimics the complexity of <i>in vivo</i> systems. This project will combine natural hydrogels with synthetic short peptide hydrogels to create tuneable ECM mimics which are targeted towards different <i>in vivo</i> applications. These hybrid materials will be evaluated for tissue engineering, stem cell differentiation and controllable drug delivery.

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Supervisory team
Adam
Martin

Science
Chemistry
Lars
Ittner

Medicine
Medical Sciences
Pall
Thordarson

Science
Chemistry
adam.martin2@unsw.edu.au

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