Identifying Small Molecules that Bind to Heat Shock Protein 27

Back to search results

Heat shock protein 27 kDa (Hsp27) is a protein that is overexpressed in cancer cells, where it protects these cells from death and promotes drug resistance. Targeting HSP27 is a promising therapeutic strategy, where depleting Hsp27 levels is successfully treating patients in clinical trials. However, there are no small molecule Hsp27 inhibitors. This translational research will involve the skills of a synthetic chemist (McAlpine) to synthesize new molecules, a native mass spec expert (Donald) who will determine binding affinity for Hsp27, and a translational biologist (Phillips) who will test the lead compounds in clinically relevant models in pancreatic cancer.

Apply Now
Supervisory team
Shelli
Mcalpine

Science
Chemistry
W. Alex
Donald

Science
Chemistry
Phoebe
Phillips

Medicine
Medicine
s.mcalpine@unsw.edu.au

Apply Now

Please start your application by taking the self assessment. Download the editable MS Word version or download the non-editable PDF version (best for Mac or mobile devices). Once the self assessment form is completed, save as a PDF and upload along with your application.

One file only.
50 MB limit.
Allowed types: gif jpg png bmp eps tif pict psd txt rtf html odf pdf doc docx ppt pptx xls xlsx xml avi mov mp3 ogg wav bz2 dmg gz jar rar sit svg tar zip.
If you have not done so, please complete the self assessment PDF as noted above.