Manipulating the Synaptic Actin Cytoskeleton in Alzheimer's Disease

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The group of A/Prof Fath, has identified the tropomyosin isoform Tpm4.2, as a major gate keeper of actin filament stability and dynamics in the postsynaptic compartment of excitatory neurons. The overall aim of the PhD project is to decipher the functional role of Tpm4.2 within the postsynaptic compartment which will allow us to target the synaptic actin cytoskeleton and modulate disease progression in Alzheimer's disease. Specific project aims: [1] define the synaptic interactome of Tpm4.2. [2] decipher how Tpm4.2 regulates excitatory synapse morphology and function. [3] test if targeting Tpm4.2 allows us to modulate Alzheimer's disease pathology.

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Supervisory team
Thomas
Fath

Medicine
Medical Sciences
Emma
Sierecki

Medicine
Medical Sciences
Gary
Housley

Medicine
Medical Sciences
t.fath@unsw.edu.au

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