Understanding how changes in tissue microstructure give rise to changes in tissue mechanical properties is an unsolved challenge in biomechanics. To solve it, accurate in vivo tissue mechanical properties and the related structural information are essential. However, most reported tissue mechanical properties were measured on ex vivo postmortem samples, despite tissue mechanical properties change after death. This project proposes to overcome this limitation by characterising the effects of tissue microstructural variations on in vivo tissue mechanical properties, using Magnetic Resonance Elastography, a cutting edge imaging technique. Research outcomes will enable numerous foreseeable future applications across biomechanics, mechanobiology, and tissue engineering.
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Prince of Wales Clinical School