The HIV capsid is a protein shell protecting the viral genome on its journey to the nucleus. The capsid interacts with competing protein networks: the virus hijacks cellular proteins to cloak itself while proteins of the innate immune system recognise and destroy viral capsids. This project will (1) investigate the dynamic interactions between host cell proteins with the viral capsid in vitro and in cells using fluorescence microscopy and (2) obtain structural insight into these complexes. The aim is to resolve mechanisms by which competing protein machinery affects viral capsid stability. This approach may identify new targets for HIV therapy.
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