Bacterial infections associated with biomedical devices represent a significant public health issue, which has been exacerbated by the rapid increase of antibiotic resistance. Therefore, it is imperative to develop a coating that uses multiple mechanisms of action in order to circumvent existing mechanisms of bacterial resistance. This proposal will develop new antimicrobial coatings that harness the combination of quorum sensing inhibitors and nitric oxide-releasing agents that provide multiple layers of protection for biomedical devices while promoting wound healing. This unique strategy has the potential to prevent device related infections, reduce health care costs and advantage the Australian biomaterials industry.
Back to search results
Optometry and Vision Science