Reducing Atherosclerotic Cardiovascular Disease with a Novel Mimetic Peptide

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Atherosclerosis is a leading cause of death worldwide. Current atherosclerosis treatments lower plasma low density lipoprotein cholesterol (LDL-C) levels. However, optimal LDL-C levels are not always achieved, and disease is not often reduced, even when very low LDL-C levels are reached. It is clear that new treatments independent of LDL-C lowering are needed. We have developed a novel peptide, C-II-a, that fills this gap. Preliminary cell experiments show that C-II-a is cardioprotective. The project will use state-of-the art molecular and novel imaging approaches to determine whether C-II-a reduces atherosclerosis in animals, and improves human atherosclerotic lesion composition and stability

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Supervisory team
Kerry-Anne
Rye

Medicine
Medical Sciences
Ben
Wu

Medicine
Medical Sciences
Len
Kritharides

Medicine
Medical Sciences
k.rye@unsw.edu.au

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