This project will determine how the cytoskeleton directs the movement of signalling molecules within the cell, from cytoplasm to nucleus, in response to extracellular stimuli. We know that specific actin filaments regulate the nuclear import of key cell proliferation proteins (e.g. ERK, STATs) making them potential targets for our novel anti-cancer drugs. Significance: This project will further our understanding of how the cytoskeleton regulates cell signalling in cancer, and provide a new paradigm for biological information technology. Techniques: this study uses state-of-the art imaging modalities: live-cell imaging, super-resolution microscopy, single-molecule in vitro imaging using TIRF microscopy and fluorescence correlative microscopy.
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