Reprogramming the Stroma using Gene Silencing Nano-Drugs to Inhibit Pancreatic Tumours

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In 2016, we had a major breakthrough - we developed a hopeful nanomedicine (incredibly small drug) that could improve treatment for Australia's deadliest cancer - pancreatic cancer (PC). Our nanomedicine is an urgently needed alternative approach to tackle PC and can inhibit any tumour-promoting gene or cocktail of genes. Our nanomedicine is able to penetrate the thick scar tissue (stroma) that surrounds pancreatic tumours. This project aims to deliver gene silencing therapies (siRNA) using our nanomedicine to the surrounding scar tissue cells and reduce their tumour-promoting activity and scar tissue production in cutting-edge clinically relevant mouse models of PC.

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Supervisory team
Phoebe
Phillips

Medicine
Prince of Wales Clinical School
David
Goldstein

Medicine
Prince of Wales Clinical School
Cyrille
Boyer

Engineering
Chemical Engineering
p.phillips@unsw.edu.au

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