Rogue Germinal Centre B Cells in Autoimmune Disease

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Self-tolerance is a process that normally protects the body from attack by the immune system. When this fails, however, antibodies that target the body's own cells (autoantibodies) are produced and can cause serious autoimmune diseases such as lupus and rheumatoid arthritis. We found mutations in the FAS gene, common in autoimmune disease, lead to the development of autoantibody-producing "Rogue Germinal Centre" B cells (Immunity 2015 42:890). This project will use sophisticated models of B cell analysis to understand how Rogue Germinal Centre B Cells escape self-tolerance and how they could be controlled in patients suffering autoimmune diseases.

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Supervisory team
Robert
Brink

Medicine
St Vincent's Clinical School
Christopher
Goodnow

Medicine
St Vincent's Clinical School
Daniel
Suan

Medicine
St Vincent's Clinical School
r.brink@garvan.org.au

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