An environmental microbiological approach to defining the intestinal microbiome

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The human intestinal microbiome plays an essential role in life. Dysbiosis is described as microbiome imbalance observed with disease. However, rectifying this imbalance is problematic as healthy microbiomes are highly variable. Current therapies used to rectify dysbiosis are crude, non-efficacious and potentially dangerous as their target is ill defined. This project will utilize an environmental microbiological approach to describe the essential elements in a healthy, functional microbiome. The project outcomes will advance our understanding of the microbiome and provide a more specific and functional definition of a healthy microbiome from which therapies can developed and refined.

The ideal candidate for this project will have a background in environmental and/or medical microbiology. The candidate should have knowledge, and preferably experience, of next generation sequencing theory, techniques, bioinformatic workflow and analysis. It would also be desirable for the candidate to have knowledge and experience in statistical methodology and analysis (for example experience with the R software packages) and experience with high performance computing.

Supervisory team
Steven
Leach

Medicine
Women's & Children's Health
Brendan
Burns

Science
Biotechnology & Biomolecular Sciences
Chee Yee (Keith)
Ooi

Medicine
Women's & Children's Health
Register to Apply
Non-UNSW staff/students must Register to Apply
s.leach@unsw.edu.au