Epigenetics and drug addiction

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Advances in molecular biology highlight a role for epigenetic factors in maintaining drug addiction. We have identified a long non-coding RNA that interacts with epigenetic marks to regulate relapse to drug-seeking in an animal model. The aim of this project is to determine how self-administration of drugs of abuse lead to epigenetic modifications and the role of these modifications in relapse to drug-seeking after abstinence. The results will provide novel information about the use of gene therapy in the treatment of drug addiction.

This project combines contemporary techniques in molecular biology with an animal model of drug addiction to assess the role of epigenetic processes in relapse after abstinence. The candidate should have a background in neuroscience, molecular biology, epigenetics or neuropharmacology.

Supervisory team
Kelly
Clemens

Science
Psychology
Fred
Westbrook

Science
Psychology
Irina
Voingeanu

Science
Biotechnology & Biomolecular Sciences
k.clemens@unsw.edu.au