This project combines contemporary techniques in molecular biology with an animal model of drug addiction to assess the role of epigenetic processes in relapse after abstinence. The candidate should have a background in neuroscience, molecular biology, epigenetics or neuropharmacology.
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Advances in molecular biology highlight a role for epigenetic factors in maintaining drug addiction. We have identified a long non-coding RNA that interacts with epigenetic marks to regulate relapse to drug-seeking in an animal model. The aim of this project is to determine how self-administration of drugs of abuse lead to epigenetic modifications and the role of these modifications in relapse to drug-seeking after abstinence. The results will provide novel information about the use of gene therapy in the treatment of drug addiction.
Biotechnology & Biomolecular Sciences