How do T cells make decisions?

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T cell activation is a hallmark of the adaptive immune system. Antigen binding to the T cell receptor (TCR) induces intracellular signalling on which T cell fate decisions are based. Inappropriate decisions can lead to autoimmunity (where the immune system attacks the host organs), or immune deficiencies (where T cells fail to clear infected or cancer cells). To understand how T cell signalling encodes and processes information, our team develops novel super-resolution fluorescence microscopes (e.g. single molecule imaging) and image analyses and employs state-of-the-art molecular biology approaches. Our interdisciplinary training spans cellular immunology, molecular biology, optical physics and applied mathematics.

We are looking for highly motivated students who  

• have a background in the biological science and have a strong interest in advanced fluorescence microscopy, or

• students who have a background in (bio)physics, mathematics and optics and have a strong interest in cell and molecular biology.

We offer a unique research experience in a multidisciplinary team by tailoring research projects to the interests and experience of our students. Our research groups have expertise in T cell biology and cell engineering as well as in the development of microscopy hardware and software. We are located in the EMBL Australia Node in Single Molecule Science in state-of-the-art laboratories with custom-build fluorescence microscopes.

Supervisory team

Medical Sciences


Medical Sciences
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