Nanobiotechnology: Self-assembly of a bio-driven single molecule DNA sequencer

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Rapid DNA sequencing has revolutionised the biological and medical sciences. Yet established methods are limited by the quantity of material required and the length of DNA sequences. By harnessing nature’s nanoscopic machinery, it is now possible to sequence single molecules of DNA, which offers a more detailed view of our genetic world and is not limited by DNA sequence length, but produces complex data with inherently low signal and high background. We will develop a nanoscale self-assembling single-molecule DNA sequencer with an in built plasmonic signal amplifier. This interdisciplinary project combines methods in DNA nanotechnology, protein engineering and fluorescence microscopy.

The candidate will be enthusiastic about discovery and innovation and ideally have training in both the physical and biological sciences. In addition, they would have specific technical expertise in one or more of the following areas:

  • DNA nanotechnology
  • Fluorescence microscopy
  • Protein engineering
  • Computer programming
Supervisory team
Lawrence
Lee

Medicine
Single Molecule Science, The University of New South Wales
Adam
Micolich

Science
Physics
Paul
Curmi

Science
Physics
lawrence.lee@unsw.edu.au