A Systematic Analysis of the Genetic Causes of Human Osteosarcoma

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Given the dismal survival of patients with metastatic or recurrent osteosarcoma, unchanged over decades, new treatment options are urgently needed. In collaboration with investigators at NIH/Division of Cancer Epidemiology & Genetics, USA, we have taken part in the worlds largest genome-wide association study (GWAS) conducted for osteosarcoma risk and survival. Using this unique data set we will functionally investigate the top ranked genes and signalling networks identified in the GWAS. This project takes a bold and innovative approach to link human genetic studies to a mouse-modelling programme to identify novel driver genes and potentially fast-track therapeutic opportunities in osteosarcoma.

The ideal candidate should have

·       First Class Honours degree or equivalent in biomedical science, molecular biology and/or immunology

·       Intrinsic curiosity about cancer biology and a passion for learning

·       Bright, hard working and committed to undertaking a PhD

·       Good communication skills

·       Ability to work individually and in a team to strive for research excellence

The PhD candidate will have access to Garvan Institutes state-of-the-art science facilities which incorporates a range of cutting edge technologies, equipment and expertise. 

Supervisory team
Prof David
Thomas

Medicine
Kinghorn Cancer Centre/Garvan Institute of Medical Research
Dr Maya
Kansara

Kinghorn Cancer Centre/Garvan Institute of Medical Research
Cancer Division
Dr Joseph
Powell

Kinghorn Cancer Centre/Garvan Institute of Medical Research
Cancer Division
m.kansara@unsw.edu.au