Explore particle-scale nature of drug transport: from blood vessels to cells

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The effective delivery of drug particles or agglomerates from blood vessels to tumour cells is a critical step for their effectiveness in treating the target tumour. This project aims to understand the particle-scale fundamentals in the transport processes by means of unique state-of-the-art numerical techniques. Of particular interests are non-spherical particles transports inside blood vessels, through vessel walls and inside tumour cells, agglomerates breakage, and the effects of key variables. The outcomes will help improve the understanding of underlying micro-scale physical processes that control nanoparticle drug delivery in basic terms, and then provide an effective tool for designing effective drug delivery to targeted regions of clinical importance.

The applicant is expected to have proven research skills including multiphysics modelling and drug delivery related experiments, research experience in drug delivery or biological process, and demonstrated track record of independent research for example published first-author research papers in high-impact journals.

Supervisory team
Yansong
Shen

Engineering
Chemical Engineering
Yong
Li

Medicine
St George Clinical School
Sophia
Gu

Engineering
Chemical Engineering
ys.shen@unsw.edu.au