A suitable training for this program would be a degree in biomedical engineering and biomedical science, ideally combined with some relevant research experience. Engineers would be expected to to have some programming background (Matlab) and/or image analysis and be open to learning biological imaging and molecular biology techniques. Biomedical science graduates will be prepared to carry out computer-intensive analysis of image datasets. Background and/or experience with biochemistry and statistics would be an advantage.
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Recently discovered as an indicator for cellular redox activity and longevity, nicotinamide adenine dinucleotide (NAD+) represents one of the most important coenzyme and substrate in biological processes. This project will focus on determining the variations of NAD+ and the metabolic state of organisms to understand their response to disease and drug treatment. We will develop methods of non-invasive quantification of endogenous NAD+ and its redox state. At the conclusion of this project we expect to establish a non-invasive method for diagnostics of NAD+ -related disorders which will be easily translated to clinical settings.