The Development of Inhibitors for Myc Oncogenic Proteins

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The majority of adult and child cancer cells are driven by abnormal expression of the Myc and MYCN oncogenes. We have identified several key genes and processes in the Myc cancer signal that represent targets for anticancer drug development and novel therapeutic approaches. We have extensive preliminary data identifying these key genes as completely novel 'onco-factors' for Myc oncogenes, acting in a forward feedback expression loop to drive both Myc expression and tumorigenesis. We will develop lead compounds and optimise therapeutic approaches we have previously discovered for anticancer treatment in Myc-driven cancers.

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Supervisory team
Belamy
Cheung

Medicine
Women's and Children's Health
Glenn
Marshall

Medicine
Women's and Children's Health
Daniel
Carter

Medicine
Women's and Children's Health
bcheung@ccia.unsw.edu.au

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