Development of Novel Biomarkers for Facial Nerve Injury

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The project will generate new biomarkers that will guide treatment for facial palsy, a condition that affects eye health, oral continence and emotional expression and communication. Nerve function will be assessed using nerve excitability techniques that have been developed by the Krishnan group. Nerve structure will be evaluated using high voxel diffusion tensor imaging and nerve metabolic activity will be analysed using translocator protein Positron Emission Tomography scanning. The results will be correlated with clinical variables and with the assessment of facial motor movements, using 3D face imaging, a technique developed by Prof Lovell and Prof Clark. One of the key elements of this project is to usher in a new era in Head and Neck surgical oncology by establishing the utility of diffusion tensor imaging and 3D face imaging as marker of disease severity and surgical outcomes.

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Supervisory team
Arun
Krishnan

Medicine
Prince of Wales Clinical School
Nigel
Lovell

Engineering
Graduate School of Biomedical Engineering
Jonathan
Clark

Medicine
South Western Sydney Clinical School
arun.krishnan@unsw.edu.au

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