Mathematical Biophysics: Single Molecule Fluorescence and Protein-Protein Binding

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The project aims to elucidate the molecular mechanisms that drive the self-assembly of functionally distinct actin tropomyosin filaments using mathematical modelling and single-molecule biophysics. Data from surface chemistry, microfluidics and fluorescence microscopy will quantitate the interactions between tropomyosins and actin filaments at high temporal resolution. The project will determine binding kinetics, test models for cooperativity, assess competition between tropomyosin isoforms and test drugs disrupting the stability of the actin cytoskeleton. The outcome is the first quantitative and predictive model of the actin cytoskeleton. The work will reveal principles for co-assembly of specialised structures in the crowded cellular environment.

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Supervisory team
Adelle
Coster

Science
Mathematics and Statistics
Bruce
Henry

Science
Mathematics and Statistics
Peter
Gunning

Medicine
Medical Sciences
A.Coster@unsw.edu.au

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