Cell shape and fate are intrinsic manifestations of form and function. Before specialisation, the stem cell serves as a sensor and actuator; its architecture emerges from its local mechanical and biochemical milieu as the cell adapts over time. We propose the engineering, manufacture and delivery of novel polymeric drug carriers to control the spatial and temporal deployment of cytoskeleton modulating agents to the cell's interior. Specifically tailored polymeric carriers (e.g. polymeric nanocapsules) will be designed and synthesized via mainly advanced heterogeneous polymerisation techniques. This coupled approach will provide a basis to elucidate mechanisms underlying the stem cell's innate capacity to adapt to mechanical stimuli as well as the role of mechanoadaptation in cell health that scales to tissue - organ - and organism health.
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